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Esportes de a？？o: notas para uma pesquisa acadêmica
Brand？o, Leonardo;
Revista Brasileira de Ciências do Esporte , 2010, DOI: 10.1590/S0101-32892010000400005
Abstract: this article aims to suggest some possible ways to think, academically, about the inclusion of action sports in brazil, taking as main reference the skateboard from a historical approach. some elements are discussed about the beginning of this activity in the country but also the stress caused by issues that pass between their marginalization and esportivization
Evaluation of early abnormalities of the sensory retina in a hypercholesterolemia experimental model: an immunohistochemical study
Torres, Rogil José de Almeida;Maia, Maurício;Précoma, Dalton Bertolin;Noronha, Lucia;Luchini, Andréa;Précoma, Leonardo Brand？o;Souza, Greyce Kelly de;Muccioli, Cristina;
Arquivos Brasileiros de Oftalmologia , 2009, DOI: 10.1590/S0004-27492009000600010
Abstract: purpose: the aim of this study is to demonstrate the early changes of the sensory retina induced by hypercholesterolemia in an experimental model. methods: new zealand rabbits were divided into two groups: cg (control group) was fed a normal diet for 6 weeks. g1 was initially fed a 1% cholesterol diet for two weeks and from the 14th day on a 0.5% cholesterol diet until the 42nd day. the eyes underwent an immunohistochemical analysis with monoclonal antibodies anti-calretinin and anti-glial fibrillary acidic protein (gfap). results: g1 cells and cell elements presented significant immunoreactivity to anti-calretinin. no immunoreactivity to anti-glial fibrillary acidic protein was observed in both groups. conclusion: this study has shown that a hypercholesterolemic diet may induce early changes in the sensory retina in rabbits. the anti-calretinin monoclonal antibody was able to reveal calcium accumulation inside the nerve cells.
Aumento da express？o do MCP-1 coroidal e escleral em modelo experimental de hipercolesterolemia
Torres, Rogil José de Almeida;Noronha, Lucia de;Casella, Antonio Marcelo Barbante;Lumikoski, Thaís Isabel;Précoma, Leonardo Brand？o;Torres, Caroline Luzia de Almeida;Luchini, Andréa;Sturzeneker, Mario Claudio Soares;Précoma, Dalton Bertolim;
Arquivos Brasileiros de Oftalmologia , 2012, DOI: 10.1590/S0004-27492012000100010
Abstract: purpose: the aim of this study is to experientially demonstrate that a cholesterol-enriched diet induces an increase in the mcp-1 expression in the choroid and sclera. method: new zealand rabbits were divided into two groups: gn (normal diet group) of 8 rabbits (8 eyes) was fed a standard rabbit diet for 4 weeks; gh (hypercholesterolemic group) of 13 rabbits (13 eyes) was fed a 1% cholesterol enriched diet for 8 weeks. total serum cholesterol, triglyceride, hdl cholesterol and fasting blood glucose exams were performed at the start of the experiment and at the euthanasia time. after gh 8th week and gn 4th week animals were euthanized and their eyes underwent immunohistochemical analysis with the anti-mcp-1 antibody. results: the diet has induced a significant increase in gh total cholesterol and triglyceride levels when compared with ng (p<0.001). there was a significant increase in the mcp-1 expression in gh choroid and sclera in relation to gn (p<0.001). conclusion: this study has revealed that the hypercholesterolemic diet in rabbits induces an increase in the mcp-1 expression in the choroid and sclera.
Do children with central venous line (CVL) dysfunction have increased risk of symptomatic thromboembolism compared to those without CVL-dysfunction, while on cancer therapy?
Halton Jacqueline,Nagel Kim,Brand？o Leonardo R,Silva Mariana
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-314
Abstract: Background Thromboembolism (TE) and infection are two common complications of central venous line (CVL). Thrombotic CVL-dysfunction is a common, yet less studied, complication of CVL. Two retrospective studies have reported significant association of CVL-dysfunction and TE. Recent studies indicate association of CVL-related small clot with infection. Infection is the most common cause of non-cancer related mortality in children with cancer. We and others have shown reduced overall survival (OS) in children with cancer and CVL-dysfunction compared to those without CVL-dysfunction. Despite these observations, to date there are no prospective studies to evaluate the clinical significance of CVL-dysfunction and it’s impact on the development of TE, infection, or outcome of children with cancer. Study design This is a prospective, analytical cohort study conducted at five tertiary care pediatric oncology centers in Ontario. Children (≤ 18 years of age) with non-central nervous system cancers and CVL will be eligible for the study. Primary outcome measure is symptomatic TE and secondary outcomes are infection, recurrence of cancer and death due to any cause. Data will be analyzed using regression analyses. Discussion The overall objective is to delineate the relationship between CVL-dysfunction, infection and TE. The primary aim is to evaluate the role of CVL-dysfunction as a predictor of symptomatic TE in children with cancer. We hypothesize that children with CVL-dysfunction have activation of the coagulation system resulting in an increased risk of symptomatic TE. The secondary aims are to study the impact of CVL-dysfunction on the rate of infection and the survival [OS and event free survival (EFS)] of children with cancer. We postulate that patients with CVL-dysfunction have an occult CVL-related clot which acts as a microbial focus with resultant increased risk of infection. Further, CVL-dysfunction by itself or in combination with associated complications may cause therapy delays resulting in adverse outcome. This study will help to identify children at high risk for TE and infection. Based on the study results, we will design randomized controlled trials of prophylactic anticoagulant therapy to reduce the incidence of TE and infection. This in turn will help to improve the outcome in children with cancer.
Expans？o geográfica da leishmaniose visceral no Estado de Pernambuco
Dantas-Torres, Filipe;Brand？o-Filho, Sinval P.;
Revista da Sociedade Brasileira de Medicina Tropical , 2006, DOI: 10.1590/S0037-86822006000400007
Abstract: this study aimed to demonstrate the geographical expansion of visceral leishmaniasis in pernambuco state, brazil. with data on the number of visceral leishmaniasis cases notified from 1990 to 2001, maps showing the biannual evolution of the geographical distribution of the disease per municipality were elaborated. a map of the cumulative geographical distribution of the cases registered during the whole period was also constructed. from 1990 to 2001, 1,737 cases of visceral leishmaniasis were notified in pernambuco. in 1990, 15.2% (n = 28) of the municipalities notified cases of the disease. in contrast, this percentage increased to 78.3% (n = 144), over an eleven-year period. the map of cumulative geographical distribution during the whole period shows a notable concentration of cases in agreste and sert？o. a notable geographical expansion of visceral leishmaniasis in pernambuco also occurred, probably reflecting the low impact of the current control measures and, possibly, an improvement in the notification system.
Visceral leishmaniasis in Brazil: revisiting paradigms of epidemiology and control
Dantas-Torres, Filipe;Brand？o-Filho, Sinval Pinto;
Revista do Instituto de Medicina Tropical de S？o Paulo , 2006, DOI: 10.1590/S0036-46652006000300007
Abstract: in the last 20 years, despite the known underestimation of cases, brazil registered a marked increase in the incidence of visceral leishmaniasis. the main goal of this review is to reflect on some aspects of this zoonosis in brazil and also to encourage the discussion in order to find more viable, effective and affordable strategies to be implemented by the brazilian leishmaniasis control program. the current situation of visceral leishmaniasis in brazil might be seen as a paradox: the most important aspects of the disease are known, but so far the control of this disease has not yet been achieved. the current control strategies have not been able to prevent the geographical expansion, and even a rise in the incidence and lethality of visceral leishmaniasis. there is a need not only for a better definition of priority areas, but also for the implementation of a fieldwork monitoring system to the disease surveillance that could permit a further evaluation of the control program in areas where visceral leishmaniasis is endemic.
A leishmaniose visceral é uma doen a endêmica em Recife, Pernambuco?
Dantas-Torres Filipe,Brand？o-Filho Sinval Pinto
Revista da Sociedade Brasileira de Medicina Tropical , 2005,
Abstract:
The Many Difficulties and Subtleties in the Cognitive Assessment of Chronic Hepatitis C Infection
Abrantes, Jefferson,Brand？o – Mello, Carlos Eduardo,Torres, Daniel Simplicio
- , 2020, DOI: https://doi.org/10.1155/2020/9675235
Abstract: Since the discovery of HCV in 1989, several diseases have been related to chronic infection by this virus. Often, patients with hepatitis C virus (HCV) complain of cognitive impairment even before the development of hepatic cirrhosis, which they described as “brain fog.” Several studies have proposed a link between chronic HCV infection and the development of cognitive alterations, but the inclusion of confounding factors in their samples significantly limits the analysis of the results. In this article, we will give an overview about cognitive dysfunction in patients with HCV
In Vitro Evaluation of the Potential Antioxidant of Bidens segetum Mart. ex Colla (Asteraceae) in Melanocyte and Melanoma Cells  [PDF]
Simone Dias Franco, Marcelo José Pena Ferreira, Fabiana Henriques Machado de Melo, Jaqueline Pereira Moura Soares, Luce Maria Brand？o Torres
Journal of Biosciences and Medicines (JBM) , 2019, DOI: 10.4236/jbm.2019.712010
Abstract: Bidens segetum Martius ex Colla known as the “picão do mato”, is an herbaceous plant that occurs in the Cerrado biome of some Brazilian states. Among the species of Bidens, we highlight B. pilosa known as “picão preto”, of which several activities are reported as antioxidant and antibacterial. Ethanolic extract from Bidens segetum (EEBs) showed an-tioxidant potential when analyzed by free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and antifungal activity against Cladosporium cladosporiodes and C. sphareospermum fungi. PFFR3.3 subfraction from EEBs has 81.5% of 5-O caffeoylquinic acid (5-CQA) and potential antioxidant (DPPH). However, PFFR3.3 did not decrease superoxide anion in metastatic melanoma cells by dihydroeth-idium assay (DHE). PP4 subfraction is a mixture of polyacetylenes that has antifungal (Cladosporium) and antioxidant activity, since reduced superoxide anion amount in melanoma cells after 5 min of treatment. However, no dose-response and time-response curve were observed, not even with the authentic standard (5-CQA). Complementary chemical studies will be performed to confirm the polyacetylenes and 5-CQA structures present in the EEBs from B. segetum and new methodologies should be performed to confirm the antioxidant activity of these com-pounds and the effects on melanocytes and melanomas.
Dental enamel around fixed orthodontic appliances after fluoride varnish application
Gontijo, Leonardo;Cruz, Roberval de Almeida;Brand？o, Paulo Roberto Gomes;
Brazilian Dental Journal , 2007, DOI: 10.1590/S0103-64402007000100011
Abstract: poor oral hygiene has been considered one of the main problems routinely faced in the orthodontic treatment. orthodontic appliance creates an environment that provides mineral loss from the dental enamel. such condition is clinically seen as white spot lesions and cavitations in the most severe cases. the aim of this study was to evaluate the effects of a fluoride varnish application as a caries prevention method for clinical orthodontics. the experiment analyzed dental enamel adjacent to orthodontics accessories after treatment. in addition, it was observed the calcium, phosphorus and fluoride contents on enamel treated with a fluoride varnish. the results showed that fluoride varnish application is a simple and fast technique that could be useful in preventing enamel demineralization associated to orthodontic treatment. scanning electron microscopy revealed significant amount of calcium fluoride-like material deposited on enamel and energy dispersive x-ray analysis demonstrated a large incorporation of calcium and fluoride to the enamel of the treated specimens. it was concluded that fluoride varnish could indeed be considered an efficient preventive method to enhance enamel resistance against the cariogenic challenges during orthodontic therapy.
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